1998 Nobel Prize for Medicine and/or Physiology
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How this Discovery Applies to Hemoxide II
“Nitric Oxide (NO) is a free radical gas in the body that acts as a powerful regulator of circulation (it is an endogenous vasodilator) and a neurotransmitter (it helps the processing of nerve signals as they cross synapses). In 1998 Nobel Prize for Medicine and/or Physiology was awarded jointly to Robert F. Furchgott, Louis J. Ignarro and Ferid Murad for their Discovery of “Nitric Oxide as a Signaling Molecule in the Cardiovascular System”.
Dr Louis Ignarro stated, “Nitric oxide deficiency can contribute to nearly every major disease of our times”.
Science Magazine called nitric oxide ‘Molecule of the Year’ – approximately 5 years before the Nobel Prize was awarded.
Dr. Valentin Fuster, President of the American Heart Association stated, “The discovery of nitric oxide and its function is one of the most important in the history of cardiovascular medicine”.
“Nitric oxide is your body’s strongest self-defense against heart attacks and strokes”, Dr. John Cooke, Director of Vascular Medicine, Stanford University Medical School, CA, USA, and author of, “The Cardio Vascular Cure”.
There have been close to 15,000 articles published world wide in medical and scientific journals since 1980 on the benefits of nitric oxide. These health effects impact conditions including: cardiovascular health, sexual dysfunction, diabetes, cancer treatment, pulmonary problems, kidney function, brain function and much more.
L-Arginine as a precursor to NO
L-Arginine is one of the 20 amino acids that make up proteins; it is the only amino acid that generates significant amounts of NO. L-Arginine is released from proteins and small peptides in the small intestine and is then absorbed along with other amino acids into the circulatory system. It is then delivered to each cell in the body. Some of the L-Arginine is metabolized for NO Synthesis and some is used for protein synthesis. NO Synthesis occurs in endothelial cells, these are the small cells that make up capillaries and line every blood vessel and lymph duct in the body. If the enzyme that makes NO and its co-factors are available in adequate amounts L-Arginine is converted to NO.
NO & Diabetes
In diabetic patients, atherosclerotic disease often occludes a portion of a vessel so that the endothelial cells are not able to properly absorb L-Arginine. If the endothelial cell can’t absorb L-Arginine, then NO synthesis will be impaired. More over, if atherosclerotic disease is present, oxygen delivery to cells is impaired. This molecular oxygen is one of the cofactors needed by the enzyme to generate NO from L-Arginine. When the NO diffuses into the smooth muscle cells that surround the endothelial lining of blood vessels it causes a biological chain of events that lead to relaxation of these smooth muscle cells. This relaxation results in increased blood flow. Tissues that are deprived of normal circulation (hypoxic) cannot produce as much NO as well-oxygenated tissues. Thus an initial period of hypoxia leads to declines in NO production and reduced blood flow. Over time, this condition escalates. Both circulation and neural function are impaired in Diabetic Patients, particularly if tight glucose control is not maintained. It is no wonder that diabetes creates a condition where kidney, heart, and eye problems become worse and wound healing is progressively impaired.
A Summary of Hemoxide II Conceptual Development;
Hemoxide II is a nutritional supplement that was developed to promote healthy blood flow in individuals with Diabetes, by supporting the production of nitric oxide. When this gaseous molecule, Nitric Oxide is a produced in the body it results in relaxing the walls of blood vessels. When the body has sufficient Nitric Oxide vessels remain in an open state and blood flow throughout the body is enhanced.
Hemoxide II is a proprietary blend of amino acids, herbs, vitamins and minerals, which are blended together under a proprietary method known as N.P S. (Neurotransmitter Production Support). The N.P.S. delivery system is designed to allow relatively small quantities of nutrients to substantially increase neurotransmitter synthesis via a synergistic effect. It is this synergistic effect that allows Hemoxide IIÔ to deliver the precursors for NO Synthesis while using very small (milligram) quantities of L-Arginine, unlike other products that use large amounts of L-Arginine. This is crucial for Diabetics since multi-Gram quantities of L-Arginine can be dangerous because of its insulin blocking effects.
Neurotransmitter Production Support (NPS)
Neurotransmitters can only be formed in the body from a select number of amino acids and other nutrients. Additionally, in order for neurotransmitters to be produced, certain nerve cells must be activated. Unless theses nerve cells are activated, simply supplying nutrients is insufficient to increase production of neurotransmitters.
The key to increasing the amount of the neurotransmitter produced, (nitric oxide), by the body is to supply the needed nutrients while simultaneously activating the nerve cells that produce the desired neurotransmitter. This concept forms the basis of the proprietary formulation strategy known as N.P.S. that is utilized to create new products.
In order for a neurotransmitter to be synthesized, two things need to happen. First the nutrient for the neurotransmitter production (its precursor) must be available. Second, a neuron must be releasing a neurotransmitter in order to initiate neurotransmitter production. Triggering release of neurotransmitter activates cellular intake of its precursor in order to replenish what was released by increasing neurotransmitter synthesis. This is the key to N.P.S.’s synergistic actions.
Prior to development of N.P.S. these results could only be produced by multi-gram quantities of precursors, or could not be achieved at all. It combines milligram amino acid dosages and delivers macro-gram effects to increase circulating nitric oxide.
To illustrate the N.P.S. concept, imagine a factory. In order for a factory to convert raw materials into a finished product, the assembly line must be turned on. If the assembly line remains inactive, the raw materials will not be converted into a finished product. N.P.S. products are designed to “turn on” cells that change “raw materials” into Neurotransmitters.
Conclusion
As you can see, Nitric Oxide is crucial to the health of a diabetic. Nitric oxide also has a wide variety of other effects including killing bacteria and viruses, and improving healing of wounds and ulcers. Stress, aging, injuries, and fighting disease-causing organisms can all deplete the body of nitric oxide. These facts make it critical to support the production of NO.
Hemoxide II is formulated to nutritionally support blood flow in individuals with Diabetes, Arteriosclerosis, or Hypertension by supporting Nitric Oxide Synthesis. Since a deficiency of nitric oxide is involved in the pathophysiology of diabetes, one can see the importance of the effects of Hemoxide II for the diabetic.
Hemoxide II was formulated based on peer review literature, primarily from the basic science biochemical literature.