Hemoxide

A Neurotransmitter Formula using the Nitric Oxide Pathway
System wide neurotransmitter enhancement created from Nobel Prize Winning Science

This information is intended for physicians and other licensed health care providers to use as a basis for determining whether or not to recommend these products to their clients.

Hemoxide has been clinically shown to produce nitric oxide which, according to numerous scientific studies¹:

• promotes system wide vasodilatation
• promotes normalized blood pressure,
  and cholesterol levels (anti-coagulant)
• reduces stress, promotes sleep/calming effect
• decreases inflammation and pain
• decreases healing time
• rejuvenates skin and hair

Nitric Oxide (eNOS) proven by the 1998 Nobel Prize winning team, is the definitive neurotransmitter behind system wide vasodilatation, which promotes system wide blood flow (eNOS) , nerve cell communication (nNOS), and immune system response (iNOS). Two of the most well known pharmaceutical drugs, nitroglycerine and sildenfil, are nitric oxide/free radical producing drugs. Concerns have arisen regarding the free radical impact of nitric oxide to oxidative stress/tolerance (nitroglycerin²) and the cGMP breakdown inhibition of sildenafil resulting in potential blood pooling at blood vessel lesion sites³.  This has opened up the opportunity for a multi-nutrient Nutraceutical application engineered to produce Nitric Oxide, nature’s nutrient delivery pathway, without the potential side effects related to the more popular pharmaceutical applications.

Hemoxide utilizes the proprietary Healthy Edge Solutions nitric oxide delivery system clinically studied (in house) and proven to produce ADNO in excess of 30 minutes (up to 4 hours). Such nitric oxide production (over the 30 minute threshold) promotes vasodilation, which increases blood flow, oxygen delivery, and nutrient delivery. Mechanisms and success of our nitric oxide pathway products are by virtue of translation of numerous studies showing applications of arginine, nitric oxide and formula ingredients (amino acids, vitamins, minerals, nutrients and herbs).

Hemoxide contains a proprietary blend of clinically studied, pharmaceutical grade Nitric Oxide amino acid precursors to include Arginine, network antioxidants to include Vitamin C^4,5, Vitamin E, N-Acetyl-L Cysteine, flavonoid regulators to include Citrus Bio Flavonoid, Echinacea and Horse Chestnut seed extract⁶, and clinically proven whole herbs to include cordyceps and turmeric.

Suggested Dosage: As a dietary supplement, for the first week, take three (3) capsules with a glass of water only, twice a day on an empty stomach (do not consume any other supplements, food, or medication one hour before or one hour after taking capsules). Starting the second week, take three (3) capsules once a day (with water only), on an empty stomach (nothing to eat an hour before or an hour after taking the capsules).

Warnings and Contraindication: Due to potential hypotensive action, caution should be taken by those on hypertension medication or having low blood pressure. Due to anti-coagulation (blood-thinning) action, Warfarin, Coumadin, and other blood-thinning medications should only be taken under strict doctor supervision. Those with continual herpes outbreaks are cautioned to purse a low Arginine diet.

Arginine: A new Therapy for Atherosclorosis? Circulation. 1997;95:311-312. Cooke, J.P., Tsao,P.

Arginine is a semiessential amino acid that, among other functions, also serves as the substrate for the enzyme NOS, which converts arginine to citrulline and NO. Normally, arginine is not rate-limiting in this reaction; the K_m for NOS is in the micromolar range, whereas intracellular levels of arginine are in the millimolar range. Under certain conditions, however, arginine administration can enhance the synthesis of NO. In hypercholesterolemic rabbits and humans, endothelium-dependent vasodilation due to NO is impaired; administration of arginine restores endothelium-dependent vasodilation. Using chemiluminescent techniques, we have shown that this effect of arginine supplementation is associated with an increased synthesis of NO by the vascular endothelium.Recent work by Bode-Boger and colleagues has revealed a likely mechanism for the enhancement of NO synthesis by arginine supplementation. These investigators discovered higher circulating levels of ADMA in hypercholesterolemic rabbits. ADMA is an endogenous competitive inhibitor of NOS.Elevated levels of ADMA have been shown to inhibit endothelium-dependent vasodilation; this effect is reversed by exogenous L-arginine….To summarize, in the present study and in other experimental models of atherosclerosis, the weight of evidence favors the hypothesis that supplemental dietary arginine exerts an antiatherogenic effect. This effect of arginine is largely due to its metabolism to NO. The accumulated data suggest that enhancement of the NOS pathway may be a novel therapeutic strategy in the treatment of atherosclerosis.

L-Arginine supplementation enhances diabetic wound healing: Involvement of the nitric oxide synthase & arginase pathways.
Journal of Metabolism: Clinical and Experimental. Volume 51, Issue 10 Pages 1269-1273 (October 2002).  Witte, MB, Thornton, F, Tantry, U., Barbul, A.

Arginine is a basic amino acid that plays several pivotal roles in cellular physiology. Like any amino acid, it is involved with protein synthesis, but it is also intimately involved with cell signaling through the production of nitric oxide and cell proliferation through its metabolism to Ornithine and the other polyamines. Because of these multiple functions, arginine is an essential substrate for wound healing processes. Numerous studies have shown that arginine supplementation can lead to normalization or improvement of healing. This article reviews the basic biochemistry and cell signaling within which arginine performs its functions. In particular, the requirement for this amino acid in tissue repair is highlighted.

Flavonoids Attenuate Cardiovascular Disease, Inhibit Phosphodiesterase, & Modulate Lipid Homeostasis in Adipose Tissue & Liver:  Experimental Biology and Medicine 231:1287-1299 (2006). Peluso, M.

Plant flavonoids are widely distributed polyphenolic compounds of the human diet. They consist of six major classes based on specific structural differences: flavonols, flavones, flavanones, catechins, anthocyanidins, and isoflavones. All of the major classes of flavonoids are comprised of three six-membered rings: an aromatic A-ring fused to a heterocyclic C-ring that is attached through a single carbon-carbon bond to an aromatic Bring. Population studies have shown that flavonoid intake is inversely correlated with mortality from cardiovascular disease, and numerous flavonoids of dietary significance have been shown to beneficially impact parameters associated with atherosclerosis, including lipoprotein oxidation, blood platelet aggregation, and vascular reactivity. Therapeutic effects of flavonoids on platelet aggregability and blood pressure have been attributed to competitive inhibition of cyclic nucleotide phosphodiesterase (PDE), an elevation in cAMP level, and subsequent activation of protein kinase A (cAMP-dependent protein kinase). In addition, flavonoids may induce neutral lipid hydrolysis from lipid stores through PDE inhibition in adipose tissue and liver. Indeed, the three-dimensional structure of many flavonoids is sterically and electrostatically compatible with the catalytic site of cAMP PDE3 and PDE4. Flavonoids have also been reported to suppress pathways of lipid biosynthesis and of very low-density lipoprotein production in cultured hepatocytes. Continued studies of the biochemical mechanisms underlying the biological effects of plant flavonoids may uncover new strategies for the treatment of cardiovascular disease, as well as associated conditions such as obesity, hepatic steatosis, and Type 2 diabetes.

Reference:

1. Murad, F. 1999. Discovery of some of the biological effects of nitric oxide and its role in cell signaling. Bioscience Reports 19(3):133-54.
2. Hirai, N., et al. 2003.  Attenuation of Nitrite Tolerance and Oxidative Stress by an Angiotensin II Receptor Blocker in Patients with Coronary Spastic Angina.  Circulation 2003; 108: 1445-1450.
3. University Of Illinois At Chicago (2003, January 10). Viagra Deaths Explained By New Understanding Of Platelet Clumping. ScienceDaily. Retrieved June 8,      2009, from http://www.sciencedaily.com­ /releases/2003/01/030110193129.htm
4. Chambers, J.C., et al. 1999. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: An effect reversible with Vitamin C therapy. Circulation 99: 1156-60.
5. Taddei, S. et al. 1998. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 97: 2222-29.
6. Pittler, M.H. , and E. Ernst. 1998. Horse Chestnut Seed extract for chronic venous insufficiency – a criteria-based systemic review. Arch Dermatol 134:1356-60.
7. Cooke, J.P., Is atherosclerosis an arginine deficiency disease? J. Investigative Medicine, 46(1998) 377-380.
8. Cooke, J.P., Role of nitric oxide in progression and regression of atherosclerosis, West J. Med, 164 (1996) 419-424.
9. Fields, C.E. and Makhoul, R.G., Vasometer tone and the role of nitric oxide, Semin. Vascular Surgery., 11 (1998) 181-192.
10. Lyons, D., Impairment and restoration of nitric oxide-dependent vasodilation in cardiovascular disease, Int. J. Cardiology., 62 Suppl 2 (1997) S101-S109.
11. Shi H.P, et al.  Supplemental L-arginine enhances wound healing following trauma/hemorrhagic shock. WOUND REP REG Vol.15;No.1;Page 66-70(2007)